HCID 178476515, compound → HCID 178476539, compound

HRID 1086122Notes

Reaction equation

HRID 1086122 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([NH:12][C@H:13]([C:18]([NH:20][C@H:21]([C:28]([NH:30][C@H:31]([C:39]([N:41]1[CH2:52][CH2:51][CH2:50][C@H:42]1[C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])=[O:40])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:38])[NH2:37])=[O:29])[CH2:22][O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].[CH3:63][C:64]([OH:66])=[O:65].[CH3:67][C:68]([OH:70])=[O:69]>C(O)(=O)C>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:18]([NH:20][C@H:21]([C:28]([NH:30][C@H:31]([C:39]([N:41]1[CH2:52][CH2:51][CH2:50][C@H:42]1[C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])=[O:40])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:37])[NH2:38])=[O:29])[CH2:22][O:23][C:24]([CH3:27])([CH3:25])[CH3:26])=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9].[CH3:63][C:64]([OH:66])=[O:65].[CH3:67][C:68]([OH:70])=[O:69].[CH3:42][C:43]([OH:45])=[O:44]

Participants

3

Reactant 1

HCID 178476515HCID 178476515, compound

Product 1

HCID 178476539HCID 178476539, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4.4 g of Z-Arg-Ile-Ser(tBu)-Arg-Pro-OtBu diacetate (crude substance) are dissolved in about 60 ml of 90% strength acetic acid and catalytically hydrogenated in analogy to Example 1b.

Sources & evidence

ORD record
ord-7835dc2a920b40b094dfc279b98da0b6
Source dataset
uspto-grants-1991_04
Patent number
US05011825

Reaction notes

Loading…