Acetic Anhydride → HCID 11540528, compound

Participants

Reaction Steps

Acetic anhydride (1.04 ml, 11 mmol) was added to a solution of 1 g of 1-(β-D-arabinofuranosyl)-5-iodouracil from Example 4(c)(2.7 mmol) in 10 ml of dry pyridine. After stirring for 3 hours at room temperature, the solvent was evaporated and the residue was co-evaporated with CH2Cl2 several times. The residue was triturated with ethanol, the solid filtered and dried to give 1.256 g (93%) of the title compound, melting at 175°-9° C.

Provenance & Evidence