HCID 19826898, compound → HCID 19826900, compound

Participants

Reaction Steps

Zinc powder (0.19 g) was added to a stirred solution of 1,3-dibromo-6-methyl-4-phenyl-5,6,7,8-tetrahydro-4H-thieno[3,4-d]azepine (0.58 g) in acetic acid (10 ml) and the mixture heated under reflux for 5 hours under nitrogen. The mixture was evaporated, water (20 ml), 0.880 ammonia solution (5 ml) added, and extracted with dichloromethane (2×20 ml). The extracts were dried, filtered, evaporated and the residue chromatographed (silica, 1% methanol in dichloromethane) to give 1-bromo-6-methyl-4-phenyl-5,6,7,8-tetrahydro-4H-thieno [3,4-d]azepine as an oil. Later column fractions contained 6-methyl-4-phenyl-5,6,7,8-tetrahydro-4H-thieno[3,4-d]azepine.

Provenance & Evidence