Ammonia → HCID 14207628, compound

HRID 1086175Notes

Reaction equation

HRID 1086175 reaction equation
[Br:1][C:2]1[N:3]=[C:4]([NH:16][CH3:17])[C:5]2[N:6]([CH:8]=[C:9]([C:11](OCC)=[O:12])[N:10]=2)[CH:7]=1.[NH3:18]>>[Br:1][C:2]1[N:3]=[C:4]([NH:16][CH3:17])[C:5]2[N:6]([CH:8]=[C:9]([C:11]([NH2:18])=[O:12])[N:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 14207609HCID 14207609, compound

Product 1

HCID 14207628HCID 14207628, compoundYield 40%

Procedure

A suspension of 0.470 g (1.57 mmol) of ethyl 6-bromo-8-methylaminoimidazo[1,2-a]pyrazine-2-carboxylate, obtained according to the process described in Example 3, in 50 ml of concentrated aqueous ammonia solution, is brought to reflux for 4 hours. After the mixture is cooled, the precipitate is drained, washed and dried. 0.160 g (Yld=40%) of 6-bromo-8-methylaminoimidazo[1,2-a]pyrazine-2-carboxamide (m.p. 312° C.) is obtained.

Workup

  1. customobtained
  2. temperatureto reflux for 4 hours
  3. temperatureAfter the mixture is cooled
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-b750ed0ff66f430f9a2324e2c6419be5
Source dataset
uspto-grants-1991_07
Patent number
US05028605

Reaction notes

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