Ethyl bromopyruvate → ethyl imidazo[1,2-a]pyrazine-2-carboxylate

HRID 1086176Notes

Reaction equation

HRID 1086176 reaction equation
[NH2:1][C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1.Br[CH2:9][C:10](=O)[C:11]([O:13][CH2:14][CH3:15])=[O:12]>>[N:1]1[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][N:3]2[CH:4]=[CH:5][N:6]=[CH:7][C:2]=12

Participants

3

Reactant 2

HCID 66144Ethyl bromopyruvateHCID 78747Aminopyrazine

Product 1

HCID 11845418ethyl imidazo[1,2-a]pyrazine-2-carboxylateYield 25%

Procedure

This derivative is obtained according to the technique described in Example 3, stage B, by reacting 2-aminopyrazine and ethyl bromopyruvate. Ethyl imidazo[1,2-a]pyrazine-2-carboxylate (m.p. 179° C., Yld=25%) is obtained.

Workup

  1. customThis derivative is obtained

Sources & evidence

ORD record
ord-2838e3732f6b4bc7a020201c317b5fe9
Source dataset
uspto-grants-1991_07
Patent number
US05028605

Reaction notes

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