1,3-Dichloroacetone → HCID 14207603, compound

HRID 1086177Notes

Reaction equation

HRID 1086177 reaction equation
[Cl:1][CH2:2][C:3]([CH2:5]Cl)=O.[NH2:7][C:8]1[C:13]([N:14]([CH3:16])[CH3:15])=[N:12][C:11]([Br:17])=[CH:10][N:9]=1>>[Br:17][C:11]1[N:12]=[C:13]([N:14]([CH3:16])[CH3:15])[C:8]2[N:9]([CH:5]=[C:3]([CH2:2][Cl:1])[N:7]=2)[CH:10]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 142076275-Bromo-N~3~,N~3~-dimethylpyrazine-2,3-diamine

Product 1

HCID 14207603HCID 14207603, compound

Procedure

1.17 g (9.2 mmol) of 1,3-dichloroacetone is added dropwise to a solution of 2 g (9.2 mmol) of 2-amino-5-bromo-3-dimethylaminopyrazine. After 3 hours under reflux, the alcohol is evaporated off under reduced pressure and the residue taken up with water, alkalinized and extracted with dichloromethane. After purification by chromatography, 6-bromo-2-chloromethyl-8-dimethylaminoimidazo[1,2-a]pyrazine is obtained.

Workup

  1. temperatureAfter 3 hours under reflux
  2. customthe alcohol is evaporated off under reduced pressure
  3. extractionextracted with dichloromethane
  4. customAfter purification by chromatography

Sources & evidence

ORD record
ord-9b2556e3dadc437485e2e47ddc64cf3d
Source dataset
uspto-grants-1991_07
Patent number
US05028605

Reaction notes

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