Methanol → HCID 15150717, compound

HRID 1086189Notes

Reaction equation

HRID 1086189 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])[CH:5]=[CH:6][C:7]=1[NH2:8].CO.[CH:19](=O)[CH:20]=O>O>[C:11]1([C:9]([C:4]2[CH:3]=[C:2]3[C:7](=[CH:6][CH:5]=2)[N:8]=[CH:20][CH:19]=[N:1]3)=[O:10])[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 7860GlyoxalHCID 1355203,4-Diaminobenzophenone

Product 1

HCID 15150717HCID 15150717, compoundYield 59.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred solution of 30 parts of (3,4-diaminophenyl) phenylmethanone in 240 parts of methanol were added 30 parts of an ethanedial solution in water 40%. The reaction mixture was stirred for 3 hours at reflux temperature. After cooling to room temperature, the precipitated product was filtered off, washed with methanol and dried, yielding 20 parts (59.3%) of phenyl (6-quinoxalinyl)methanone; mp. 120° C. (interm. 2).

Workup

  1. temperatureat reflux temperature
  2. filtrationthe precipitated product was filtered off
  3. washwashed with methanol
  4. customdried

Sources & evidence

ORD record
ord-d7b5e75c12274bc5ae7514975b7248fc
Source dataset
uspto-grants-1991_07
Patent number
US05028606

Reaction notes

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