Methanol → HCID 19875867, compound

HRID 1086190Notes

Reaction equation

HRID 1086190 reaction equation
[C:1]1([C:7]([C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[N:15]=[CH:14][CH:13]=[N:12]3)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO.[BH4-].[Na+]>O>[C:1]1([CH:7]([C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[N:15]=[CH:14][CH:13]=[N:12]3)[OH:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 15150717HCID 15150717, compound

Product 1

HCID 19875867HCID 19875867, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred and cooled (5° C.) solution of 20 parts of intermediate 2, namely phenyl (6-quinoxalinyl)methanone in 160 parts of methanol were added portionwise 3.2 parts of sodium tetrahydroborate. Upon completion, the reaction mixture was poured into water and the product was extracted with dichloromethane. The extract was washed with water, dried, filtered and evaporated to dry, yielding 20 parts (100%) of α-phenyl-6-quinoxalinemethanol as an oily residue (interm. 3).

Workup

  1. extractionthe product was extracted with dichloromethane
  2. washThe extract was washed with water
  3. customdried
  4. filtrationfiltered
  5. customevaporated
  6. customto dry

Sources & evidence

ORD record
ord-59dd487d3b884b4ab96dec7462391300
Source dataset
uspto-grants-1991_07
Patent number
US05028606

Reaction notes

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