HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178478461, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Chlorobutyronitrile | HCID 12336 | — |
| Reactant | Hydrazoic acid | HCID 24530 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178478461 | HCID 178478461 | — |
Reaction Steps
A mixture of 4-chlorobutyronitrile, (0.05 mol) sodium azide (0.20 mol) and anhydrous aluminum chloride (0.05 mol) in 100 ml of dry tetrahydrofuran is refluxed for 24 hours. After cooling to ambient temperature the reaction is acidified with ml of 15% hydrochloric acid while the hydrazoic acid generated is removed by means of an aspirator. The organic and aqueous layers are then separated and the aqueous layer extracted with ethylacetate. The combined organic extracts are dried (magnesium sulfate) and evaporated to give 5-(3-chloropropyl)tetrazole which is used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05028615 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-a33f967621004de6b211a17258574739 |
| Source note | uspto-grants-1991_07 |