Ethyl Acetate → HCID 19827119, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 300 mg of 1-[bis(4-fluorophenyl)methyl]piperazine and 280 mg of N-(1,2,3,4-tetrahydro-1-quinolyl)-2-bromopropionamide was dissolved in 20 ml of a 1:1 by volume mixture of tetrahydrofuran and N,N-dimethylformamide, and 100 mg of anhydrous potassium carbonate were added to the resulting solution. The solution was then stirred at 90° C. for 2 hours, after which ethyl acetate was added, and the organic layer was separated. The organic layer was washed three times with water, and dried over anhydrous magnesium sulfate. The solvent was then removed by evaporation under reduced pressure, and the resulting residue was subjected to silica gel thin layer chromatography using a 1:1 by volume mixture of cyclohexane and ethyl acetate as the developing solvent, to give a purified 1-[bis(4-fluorophenyl)methyl]-4-[1-(1,2,3,4-tetrahydroquinoline-1-carbonyl)ethyl]piperazine.

Provenance & Evidence