反应详情

To a solution of 1.45 g of 3-(2-indanylacetyl)-L-thioproline ethyl ester prepared in Reference Example 1 in 17 ml of ethanol was added 28 ml of 1 N sodium hydroxide, and the mixture was stirred at room temperature. After 1 hour, ethanol was evaporated under reduced pressure. Twenty (20) ml of water was added to the residue and the solution was washed with ethyl acetate. The water layer was acidified with the addition of diluted hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous magnesium sulfate. After evaporation of the solvent under reduced pressure, the residue was recrystallized from a mixed solvent of ethyl acetate and n-hexane to produce 0.76 g of 3-(2-indanylacetyl)-L-thioproline (yield: 57%).

1. customethanol was evaporated under reduced pressure
2. additionTwenty (20) ml of water was added to the residue
3. washthe solution was washed with ethyl acetate
4. additionThe water layer was acidified with the addition of diluted hydrochloric acid
5. extractionextracted with ethyl acetate
6. washThe organic layer was washed with water
7. dry with materialdried over anhydrous magnesium sulfate
8. customAfter evaporation of the solvent under reduced pressure
9. customthe residue was recrystallized from a mixed solvent of ethyl acetate and n-hexane