L-Thioproline → HCID 131716921, compound

HRID 1086270Notes

Reaction equation

HRID 1086270 reaction equation
[CH:1]1([CH2:10][C:11](Cl)=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[NH:14]1[CH2:21][S:20][CH2:19][C@H:15]1[C:16]([OH:18])=[O:17].C1(CC(Cl)=O)C2C(=CC=CC=2)CC1>>[CH:1]1([CH2:10][C:11]([CH:19]2[S:20][CH2:21][NH:14][C@@H:15]2[C:16]([OH:18])=[O:17])=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

4

Reactant 3

HCID 93176L-ThioprolineHCID 13572627HCID 13572627, compoundHCID 57095046HCID 57095046, compound

Product 1

HCID 131716921HCID 131716921, compoundYield 44%

Procedure

Colorless crystals of 3-(2-indenylacetyl)-L-thioproline were prepared in the same manner as Reference Example 10, except that 2-indenylacetyl chloride and L-thioproline were used instead of 2-indanylacetyl chloride and L-piperidin-2-ylcarboxylic acid, respectively (yield: 44%).

Sources & evidence

ORD record
ord-9105a553c6784930a86c8a46c9b4f621
Source dataset
uspto-grants-1991_07
Patent number
US05028604

Reaction notes

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