1-Indanylacetic acid → HCID 15124130, compound

HRID 1086271Notes

Reaction equation

HRID 1086271 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][CH:8]([CH2:13][C:14]([OH:16])=O)[CH2:7][CH2:6]2.[CH3:17][O:18][C:19](=[O:25])[C@@H:20]1[CH2:24][CH2:23][CH2:22][NH:21]1.C1(CC(O)=O)C2C(=CC=CC=2)CC1>>[CH3:17][O:18][C:19](=[O:25])[C@@H:20]1[CH2:24][CH2:23][CH2:22][N:21]1[C:14](=[O:16])[CH2:13][CH:8]1[CH2:7][CH2:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:9]1

Participants

4

Reactant 3

HCID 965011-Indanylacetic acidHCID 853477Methyl L-prolinateHCID 21939949(6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetic acid

Product 1

HCID 15124130HCID 15124130, compoundYield 79%

Procedure

1-(6-methoxy-1,2,3,4 tetrahydronaphthalen-2-ylacetyl)-L-proline methyl ester was prepared as an oily substance in the same manner as Reference Example 1, except that 6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylacetic acid and L-proline methyl ester were used instead of 2-indanylacetic acid and L-thioproline ethyl este respectively (yield: 79%).

Sources & evidence

ORD record
ord-2d06b2c620dc4797ad9c7675cb01fb62
Source dataset
uspto-grants-1991_07
Patent number
US05028604

Reaction notes

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