1-Indanylacetic acid → HCID 131716922, compound

HRID 1086274Notes

Reaction equation

HRID 1086274 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C@@H:2]1[CH2:11][C:12]([OH:14])=O.[CH2:15]([O:17][C:18](=[O:24])[C@H:19]1[CH2:23][S:22][CH2:21][NH:20]1)[CH3:16].C1(CC(O)=O)C2C(=CC=CC=2)CC1.C(OC(=O)[C@@H]1CSCN1)C>>[CH2:15]([O:17][C:18](=[O:24])[C@H:19]1[CH:23]([C:12](=[O:14])[CH2:11][C@H:2]2[CH2:3][CH2:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH2:1]2)[S:22][CH2:21][NH:20]1)[CH3:16]

Participants

5

Reactant 4

HCID 965011-Indanylacetic acidHCID 9990086HCID 9990086, compoundHCID 13011878Ethyl (4R)-4-thiazolidinecarboxylateHCID 13011879HCID 13011879, compound

Product 1

HCID 131716922HCID 131716922, compoundYield 83%

Procedure

Colorless crystals of 3-[(S)-(-)-1,2,3,4-tetrahydronaphthalen-2-ylacetyl]-D-thioproline ethyl ester were prepared in the same manner as in Reference Example 1, except that (S)-(-)-1,2,3,4-tetrahydronaphthalen-2-ylacetic acid and D-thioproline ethyl ester were used instead of 2-indanyl acetic acid and L-thioproline ethyl ester, respectively (yield: 83%).

Sources & evidence

ORD record
ord-b0e635ee5a6d4eebba4ae3a020420795
Source dataset
uspto-grants-1991_07
Patent number
US05028604

Reaction notes

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