HCID 131716928, compound → HCID 131716927, compound

Participants

Reaction Steps

0.63 g of 1-[3-(5-nitroindan-2-ylacetyl)-L-thioprolyl]pyrrolidine prepared in Example 29 was dissolved in a mixed solution of 9 ml of acetic acid and 6 ml of water. 1.00 g of iron powder was gradually added with stirring. After 1 hour, the iron powder was filtered. The filtrate was alkalinized using 10% sodium hydroxide and extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. After evaporating the solvent, the residue obtained was purified by silica gel chromatography to produce 0.34 g of 1-[3-(5-aminoindan-2-ylacetyl)-L-thioprolyl]pyrrolidine as a brownish and oily substance (yield: 59%).

Provenance & Evidence