Triethylamine → HCID 86744889, compound

Participants

Reaction Steps

0.53 g of 1-[1-(2-indenylacetyl)-L-prolyl]-L-prolinol prepared in Preparation Example 41 and 0.76 g of triethylamine were dissoved in 6 ml of dimethylsulfoxide. To the solution was added 1.19 g of sulfur trioxide-pyridine complex and the mixture was stirred for one hour at room temperature. The reaction mixture to which 10 ml of ice-water was added was extracted with ethyl acetate. The organic layer was washed with diluted hydrochloric acid, water, and saturated sodium hydrogen carbonate in this order. The organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue thus obtained was purified by silica gel chromatography to produce 0.29 g of 1-[1-(2-indenylacetyl)-L-prolyl]-L-prolinal as a colorless oil (yield: 55%).

Provenance & Evidence