HCID 9990086, compound → HCID 10247845, compound

HRID 1086294Notes

Reaction equation

HRID 1086294 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C@@H:2]1[CH2:11][C:12]([OH:14])=O.Cl.[NH:16]1[CH2:27][CH2:26][CH2:25][C@H:17]1[C:18]([N:20]1[CH2:24][CH2:23][S:22][CH2:21]1)=[O:19].C1C2C(=CC=CC=2)CC1CCC(O)=O.Cl.N1CSC[C@H]1C(N1CCCC1)=O>>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C@@H:2]1[CH2:11][C:12]([N:16]1[CH2:27][CH2:26][CH2:25][C@H:17]1[C:18]([N:20]1[CH2:24][CH2:23][S:22][CH2:21]1)=[O:19])=[O:14]

Participants

5

Reactant 4

HCID 9990086HCID 9990086, compoundHCID 103976563-(indan-2-yl)propionic acidHCID 70088371HCID 70088371, compoundHCID 1317169261-L-thioprolylpyrrolidine hydrochloride

Product 1

HCID 10247845HCID 10247845, compoundYield 63%

Procedure

A colorless oil of 3-{1-[(S)-(-)-1,2,3,4-tetrahydronaphthalen-2-ylacetyl]-L-prolyl}thiazolidine was prepared in the same manner as in Example 25, except that (S)-(-)-1,2,3,4-tetrahydronaphthalen-2-ylacetic acid and 3-L-prolylthiazolidine hydrochloride were used instead of 3-(indan-2-yl)propionic acid and 1-L-thioprolylpyrrolidine hydrochloride, respectively (yield: 63%).

Sources & evidence

ORD record
ord-8987d779508d41f9864845410c093837
Source dataset
uspto-grants-1991_07
Patent number
US05028604

Reaction notes

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