HCID 10058342, compound → HCID 131716940, compound

HRID 1086297Notes

Reaction equation

HRID 1086297 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C@H:2]1[CH2:11][C:12]([OH:14])=O.Cl.[NH:16]1[CH2:27][S:26][CH2:25][C@@H:17]1[C:18]([N:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1)=[O:19].C1C2C(=CC=CC=2)CC1CCC(O)=O.Cl.N1CSC[C@H]1C(N1CCCC1)=O>>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C@H:2]1[CH2:11][C:12]([CH:25]1[S:26][CH2:27][NH:16][C@H:17]1[C:18]([N:20]1[CH2:21][CH2:22][CH2:23][CH2:24]1)=[O:19])=[O:14]

Participants

5

Reactant 4

HCID 10058342HCID 10058342, compoundHCID 103976563-(indan-2-yl)propionic acidHCID 131208778HCID 131208778, compoundHCID 1317169261-L-thioprolylpyrrolidine hydrochloride

Product 1

HCID 131716940HCID 131716940, compoundYield 59%

Procedure

Colorless crystals of 1-{3-[(R)-(+)-1,2,3,4-tetrahydronaphthalen-2-ylacetyl]-D-thioprolyl}pyrrolidine were prepared in the same manner as in Example 25, except that (R)-(+)-1,2,3,4-tetrahydronaphthalen-2-ylacetic acid and 1-D-thioprolylpyrrolidine hydrochloride were used instead of 3-(indan-2-yl)propionic acid and 1-L-thioprolylpyrrolidine hydrochloride, respectively (yield: 59%).

Sources & evidence

ORD record
ord-6460609aa1334f0197b3e185069bb44a
Source dataset
uspto-grants-1991_07
Patent number
US05028604

Reaction notes

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