HCID 9990086, compound → HCID 131716941, compound

HRID 1086298Notes

Reaction equation

HRID 1086298 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C@@H:2]1[CH2:11][C:12]([OH:14])=O.Cl.[NH:16]1[CH2:27][S:26][CH2:25][C@H:17]1[C:18]([N:20]1[CH2:24][CH2:23][S:22][CH2:21]1)=[O:19].C1C2C(=CC=CC=2)CC1CCC(O)=O.Cl.N1CSC[C@H]1C(N1CCCC1)=O>>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C@@H:2]1[CH2:11][C:12]([CH:25]1[S:26][CH2:27][NH:16][C@@H:17]1[C:18]([N:20]1[CH2:24][CH2:23][S:22][CH2:21]1)=[O:19])=[O:14]

Participants

5

Reactant 4

HCID 9990086HCID 9990086, compoundHCID 103976563-(indan-2-yl)propionic acidHCID 70384933HCID 70384933, compoundHCID 1317169261-L-thioprolylpyrrolidine hydrochloride

Product 1

HCID 131716941HCID 131716941, compoundYield 38%

Procedure

Colorless crystals of 3-{3-[(S)-(-)-1,2,3,4-tetrahydronaphthalen-2-ylacetyl]-L-thioprolyl}thiazolidine were prepared in the same manner as in Example 25, except that (S)-(-)-1,2,3,4-tetrahydronaphthalen-2-ylacetic acid and 3-L-thioprolylthiazolidine hydrochloride were used instead of 3-(indan-2-yl)propionic acid and 1-L-thioprolylpyrrolidine hydrochloride, respectively (yield: 38%).

Sources & evidence

ORD record
ord-a47d7074b46a464e9b1072609efcd571
Source dataset
uspto-grants-1991_07
Patent number
US05028604

Reaction notes

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