Hydrochloric Acid → 4-[[2-(1-Methylethyl)-3-indolizinyl]sulfonyl]phenol

Participants

Reaction Steps

6.7 g (0.050 mole) of aluminium chloride are suspended in 100 ml of dichloromethane and 25 ml of ethanethiol. This suspension is stirred and cooled to 0° C. while 2.5 g of 2-isopropyl 3-p-methoxyphenylsulfonyl indolizine in dichloromethane are added. The addition takes about 15 minutes. The reaction mixture is allowed to warm to room temperature and maintained there for 45 minutes. It is poured onto ice, then 5 ml of concentrated hydrochloric acid are added with stirring. The mixture is extracted with 2 fractions of ethyl ether and the ethereal extracts are pooled. They are washed with 3 fractions of 30 ml of a 10% aqueous solution of sodium bicarbonate and the aqueous phase is acidified.

Provenance & Evidence