Hexamethylphosphoramide → HCID 12218047, compound

HRID 1086344Notes

Reaction equation

HRID 1086344 reaction equation
[O:1]=[C:2]([CH:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7])[C:3]([OH:5])=[O:4].[CH3:14]N(C)P(=O)(N(C)C)N(C)C>>[O:1]=[C:2]([C:6]([CH3:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7])[C:3]([OH:5])=[O:4]

Participants

3

Reactant 2

HCID 12679HexamethylphosphoramideHCID 13065771HCID 13065771, compound

Product 1

HCID 12218047HCID 12218047, compoundYield 2%

Procedure

Example 9 was repeated except that 6 ml of hexamethylphosphoric triamide was used instead of t-butyl alcohol as the solvent. A mixture of 2-oxo-3-phenylbutanoic acid (46 %) and 2-oxo-3-methyl-3-phenylbutanoic acid (2 %) was obtained.

Sources & evidence

ORD record
ord-0c472f60264f4ceeb07f9ad79a293044
Source dataset
uspto-grants-1991_07
Patent number
US05028738

Reaction notes

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