Phenylpyruvic acid → HCID 15024007, compound

Participants

Reaction Steps

By the same operation as in Example 45, 1.64 g (10 mmoles) of phenylpyruvic acid was reacted with 0.11 g (10 mmoles) of 2,3-dichloropropene in a 1N aqueous solution of sodium hydroxide (20 ml, 20 mmoles) to give 2-oxo-3-phenyl-5-chloro-5-hexenoic acid as a pale yellowish white solid. It was converted to a methyl ester by using diazomethane, and then the methyl ester was purified by silica gel column chromatography. Methyl 2-oxo-3-phenyl-5-chloro-5-hexenoate as a pure product (1.87 g; yield 74 %) was obtained.

Provenance & Evidence