Sodium hydride → HCID 54537869, compound

Participants

Reaction Steps

To a stirred suspension of 3.0 g (0.075 mol) of 60% sodium hydride dispersion, 11.0 g (0.05 mol) of 4-(2-acetoxyethoxy)benzaldehyde (Example 1) and 125 mL of dry 1,2-dimethoxyethane were added, under nitrogen, 13.9 g (0.05 mol) of dimethyl 4-methylsulfonylbenzylphosphonate. The mixture was heated at reflux for 2 hr, after which time it was cooled and poured over ca. 200 g of crushed ice under nitrogen. The crude product was filtered, washed with water and air-dried to give 17.7 g (98%) of the white solid, which was used without further purification. m.p.=175°-177° C.

Provenance & Evidence