Triethylamine → HCID 53784554, compound

Participants

Reaction Steps

To a solution of 630 mg N-methyl-N-(1-naphthylmethyl)-5-ethyl-5-hydroxy-3-heptyn-amine in CH2Cl2 are added, dropwise, at -20° 0.5 ml triethylamine and thereafter 0.21 ml mesylchloride, dissolved in CH2Cl2. The mixture is stirred for 3 hours at room temperature, washed several times with water, the organic phase is dried and evaporated. The residue is chromatographed over silica gel (with toluene/ethylacetate 4/1) to give the title compound (Compound 29) as an oil.

Provenance & Evidence