反应详情

A solution of (R)-2-(tetrazolo[1,5-a]pyrid-6-yl)oxirane (0.60 g) and (1,1-dimethyl-2-(5-benzyloxy-1H-indol-3-yl))ethyl amine (1.09 g, 3.55 mmol) in 15 ml of absolute ethanol was heated at reflux for 23 hours under an inert atmosphere. The reaction mixture was concentrated under reduced pressure to give crude product (1.59 g) which was chromatographed on silica gel (95:5:0.5 CH2Cl2 :MeOH:NH4OH) to give 1.27 g of (R)-α-[[(1,1-dimethyl-2-(5-benzyloxy-1H-indol-3-yl))ethyl)amino]methyl]tetrazolo[1,5-a]pyridine-6-methanol.

1. temperatureat reflux for 23 hours under an inert atmosphere
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customto give crude product (1.59 g) which
4. customwas chromatographed on silica gel (95:5:0.5 CH2Cl2 :MeOH:NH4OH)