反应详情

A solution of this amine (907 mg) and (R)-2-(tetrazolo[1,5-a]pyrid-6-yl)oxirane (745 mg) in 20 ml of methanol was heated at reflux for 39 hours. The reaction mixture was concentrated to dryness and chromatographed on silica gel (95:5:1 CH2Cl2 :MeOH:NH4OH) to give 1.27 g of (R)-α-[[(1,1-dimethyl-2-(2-methyl-1H-indol-3-yl))ethyl)amino]methyl]tetrazolo[1,5-a]pyridine-6-methanol.

1. temperatureat reflux for 39 hours
2. concentrationThe reaction mixture was concentrated to dryness
3. customchromatographed on silica gel (95:5:1 CH2Cl2 :MeOH:NH4OH)