(R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane → HCID 15137737, compound

Participants

Reaction Steps

A solution of 350 mg of (R)-2-(tetrazolo[1,5-a]pyrid-6-yl)oxirane and 429 mg of (S)-1-methyl-2-(5-methoxy-1H-indol-3-yl)ethyl amine (R. A. Glennon et al., Biol. Psychiatry, 18, 493 (1983) in 8 ml of methanol was heated at reflux under nitrogen for 20 hours. The reaction mixture was concentrated under reduced pressure and the residue (765 mg) was purified twice by preparative TLC on silica gel (95:5:0.5 CH2Cl2 :MeOH:NH4OH) to give 419 mg of (R)-α-[[(1(S)-methyl-2-(5-methoxy-1H-indol-3-yl)ethyl)amino]methyl]tetrazolo[1,5-a]pyridine-6-methanol.

Provenance & Evidence