1-Bromohexane → 1-Ethyl-4-nitroxypiperidine fumarate

HRID 1086491Notes

Reaction equation

HRID 1086491 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[O:9]([CH:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20]CCCC)[CH2:15][CH2:14]1)[N+:10]([O-:12])=[O:11].O(C1CCNCC1)[N+]([O-])=O.C(Br)CCCCC>C(O)C>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[CH2:19]([N:16]1[CH2:17][CH2:18][CH:13]([O:9][N+:10]([O-:12])=[O:11])[CH2:14][CH2:15]1)[CH3:20]

Participants

5

Reactant 3

HCID 81011-BromohexaneHCID 15068866HCID 15068866, compoundHCID 867448974-Nitroxy-1-hexylpiperidine fumarate

Product 1

HCID 867448961-Ethyl-4-nitroxypiperidine fumarateYield 50%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-nitroxy-1-hexylpiperidine fumarate from 4-nitroxypiperidine and n-hexyl bromide; yield 50% of theory; solvent: ethanol; m.p. 102°-103° C.

Sources & evidence

ORD record
ord-518f9525716c40e7a27445e6e935dafe
Source dataset
uspto-grants-1991_07
Patent number
US05030641

Reaction notes

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