Sodium Chloride → HCID 67915257, compound

Participants

Reaction Steps

0.50 gram 0.0027 mol) of 1,3-dimethyl-4-(acetylamino) -imidazoline-2-thione (prepared by acetylating by conventional means the 1,3 dimethyl-4-amino-4-imidazoline-2-thione described in Example V) and 0.28 gram (0.003 mol) of chloroacetone were mixed together and refluxed for two hours after which time a solution 0.428 gram of sodium iodide in 5 milliliters of acetone was added whereupon a reaction took place with the immediate formation of a precipitate of sodium chloride by product. The latter was removed by filtration and the filtrate evaporated to dryness to obtain a residue. The residue was dissolved in acetone and from the solution was recovered a solid which after purification on a Dowex-1 (Cl ) column and crystallization from isopropyl alcohol was obtained the desired 1,3-dimethyl-4-(acetylamino)-2 [(2-oxopropyl)-thio]-1H imidazolium chloride, m.p. 171°-173° C.

Provenance & Evidence