Pyrrolidine → HCID 19826200, compound

Participants

Reaction Steps

A mixture of 2.50 g (0.008 mol) of 3-[(dimethylamino)methyl]-4-oxo-9-methyl-2,3,4,9-tetrahydrothiopyrano[2,3-b]indole hydrochloride obtained in Example 1, stage E and 1.78 g (0.025 mol) of pyrrolidine in 40 ml of water is heated to reflux for 10 hours. After the mixture is cooled, the precipitate formed is drained, washed with water, dried and dissolved in 40 ml of tetrahydrofuran and the solution is treated with an ethereal solution of hydrochloric acid. The precipitate formed is drained, washed with ether and recrystallized in ethanol.

Provenance & Evidence