Cyclopentylacetyl chloride → Methyl 4-[5-(2-cyclopentylacetamido)indol-3-ylmethyl]-3-methoxybenzoate

Participants

Reaction Steps

Starting from amino-ester (A), and using a similar procedure to that described in Example 4, except using cyclopentylacetyl chloride (see also Example 98), the title compound was obtained in quantitative yield as a foam; partial NMR (250 MHz, DMSO-d6): 1.2-1.8(3m,8H, cyclopentyl ring); 2.24(m,3H, CH2CONH and --CHCH2); 3.83(s,3H, OMe); 3.93(s,3H, OMe); 3.99(br s,2H, CH2Ar); 9.57(br s,1H, NHCO); 10.79(br d,1H, --NH--).

Provenance & Evidence