Dicyclohexylcarbodiimide → HCID 14407421, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 945 mg of the product of Step D of Example 1, 30 ml of dimethoxyethane and 621 mg of Boc-L-alanine was cooled to 0° C. and 678 mg of dicyclohexylcarbodiimide were added in small fractions over 10 minutes. The mixture was stirred at 0° C. for 16 hours. After filtering, the filtrate was evaporated to dryness under reduced pressure and chromatography was carried out on silica. Elution with a cyclohexane-ethyl acetate mixture (7-3) yielded 1.3 g of the expected product with a specific rotation of [α]D =-22°±2° (c=0.7% in CH2Cl2).

Provenance & Evidence