Water → HCID 73654867, compound

Participants

Reaction Steps

4.2 g of sodium iodide and 3.7 g of zinc were added to a solution of 2.4 g of the product A of Step C of Example 1 and the reaction medium in dimethoxyethane was refluxed in the presence of water with stirring for 2 hours. 50 ml of water were added and after filtration, extraction was carried out with methylene chloride. The extracts were dried and evaporated to dryness under reduced pressure to obtain 2.3 g of crude product which was chromatographed on silica. Elution with a cyclohexane ethyl acetate mixture (5-5) yielded 1.6 g of the expected product.

Provenance & Evidence