Dicyclohexylcarbodiimide → HCID 53935213, compound

Participants

Reaction Conditions

Reaction Steps

3.9 g of the product of Step D of Example 5 were dissolved in 200 ml of dimethoxyethane and 3.63 g of N-Boc-L-alanine were added. The mixture was cooled to -5°/0° C. and after addition of 3.99 g of dicyclohexylcarbodiimide, the mixture was vigorously stirred for 16 hours at 0° C. followed by filtering and evaporating to dryness. The residue was taken up in dimethoxyethane and filtered, then evaporated to dryness and taken up in methylene chloride. After washing with a saturated solution of sodium bicarbonate, then with salt water, drying and evaporating to dryness, 7.7 g of crude product were obtained which was chromatographed on silica. Elution with a cyclohexane - ethyl acetate mixture (7-3) yielded 5.4 g of the expected product with a specific roation of [α]=-18.5°±1° (c=1.6% in CH2Cl2).

Provenance & Evidence