HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 6-methyl-5H-thiazolo-(2,3-b)-quinazolin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Chlorothiazole | HCID 76429 | — |
| Reactant | 2-Amino-6-methylbenzamide | HCID 16782469 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-methyl-5H-thiazolo-(2,3-b)-quinazolin-5-one | HCID 14100430 | 69% |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
While stirring, 22.5 g of 6-methylanthranilamide was added to 18 g of 2-chlorothiazole. The reaction mixture was heated over a 20-minute period to 140° C. and stirred for 4 hours. Water was added to the reaction mixture, and a pH of 10 was set by adding 25% strength ammonia solution. Working up in the conventional manner gave 22.3 g (69%) of compound 3; m.p. 148°-150° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05030727 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-42b06d3991d9403ca7f102aecffac76c |
| Source note | uspto-grants-1991_07 |