2-Chlorothiazole → HCID 19826352, compound

HRID 1086615Notes

Reaction equation

HRID 1086615 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([NH2:14])[C:8](=[CH:12][CH:13]=1)[C:9]([NH2:11])=[O:10])([O:3][CH3:4])=[O:2].Cl[C:16]1[S:17][CH:18]=[CH:19]N=1>>[S:17]1[C:16]2=[N:14][C:7]3[C:8]([C:9](=[O:10])[N:11]2[CH:19]=[CH:18]1)=[CH:12][CH:13]=[C:5]([C:1]([O:3][CH3:4])=[O:2])[CH:6]=3

Participants

3

Reactant 2

HCID 764292-ChlorothiazoleHCID 19826346HCID 19826346, compound

Product 1

HCID 19826352HCID 19826352, compoundYield 78.1%

Procedure

19.4 g of 4-carbomethoxyanthranilamide and 12 g of 2-chlorothiazole were stirred for 4 hours at 150° C. After working up in the conventional manner there was obtained 20.3 g (78%) of the above compound; m.p. 228°-230° C.

Sources & evidence

ORD record
ord-92164bb346444d77a640e2ce4cd95635
Source dataset
uspto-grants-1991_07
Patent number
US05030727

Reaction notes

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