Carbon Dioxide → HCID 15753030, compound

Participants

Reaction Steps

Triethylamine (4.5 g, 0.044 mol) is added dropwise to a mixture of 4-phenyl-2-(trifluoromethyl)-5(2H)-oxazolone (10.0 g, 0.043 mol), 2-chloroacrylonitrile (3.51 g, 0.43 mol) and acetonitrile (50 mL). The temperature of the reaction mixture rises to 65° C. and carbon dioxide gas evolves during the addition. After the addition is complete the reaction mixture is heated at reflux temperature for one hour, cooled to room temperature and poured into water (150 mL). The solids are collected by filtration, air-dried and dried under vacuum at 60° C. to give the title compound as a white solid (10.05 g, 97%). Identified by NMR spectral analyses.

Provenance & Evidence