Cysteamine Hydrochloride → N-[(2H-1,3-Benzodioxol-5-yl)methyl]-N'-(2-sulfanylethyl)urea

HRID 1086624Notes

Reaction equation

HRID 1086624 reaction equation
C1(O[C:8](=[O:20])[NH:9][CH2:10][C:11]2[CH:19]=[CH:18][C:17]3[O:16][CH2:15][O:14][C:13]=3[CH:12]=2)C=CC=CC=1.Cl.[NH2:22][CH2:23][CH2:24][SH:25].[OH-].[Na+]>N1C=CC=CC=1>[SH:25][CH2:24][CH2:23][NH:22][C:8]([NH:9][CH2:10][C:11]1[CH:19]=[CH:18][C:17]2[O:16][CH2:15][O:14][C:13]=2[CH:12]=1)=[O:20]

Participants

5

Reactant 3

HCID 9082Cysteamine HydrochlorideHCID 14798Sodium HydroxideHCID 888278HCID 888278, compound

Product 1

HCID 54038894N-[(2H-1,3-Benzodioxol-5-yl)methyl]-N'-(2-sulfanylethyl)urea

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

6 g (0.022 mol) of phenylpiperonylcarbamate, prepared as in example 2A, are placed in pyridine and a heterogenous suspension is obtained. Separately a solution made in a nitrogen stream of 2.75 g (0.024 mol) of cysteamine hydrochloride and of NaOH (0.96 g, 0.024 mol) is prepared. The cysteamine solution thus obtained is added to the phenylpiperonylcarbamate solution and heated while stirring for 8 hours.

Workup

  1. customa heterogenous suspension is obtained
  2. customis prepared

Sources & evidence

ORD record
ord-cb175f167d0446058f98f510274940d0
Source dataset
uspto-grants-1991_07
Patent number
US05030738

Reaction notes

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