Nitric Acid → HCID 18948914, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 9 starting with 5,6-dihydro-6-hydroxy-7-(4-trifluoromethylbenzamido)-7H-thieno[3,2-b]pyran (1.5 g, 4.04 mmol) and 90% nitric acid (2.5 mL) in acetic acid (20 mL) to give a yellow solid, 0.165 g (10%): mp 219°-220° C.; IR (KBr): 3310, 1661, 1538 and 1504 cm-1 ; MS: m/z 417 (MH+); 1H NMR (DMSO-d6): δ1.26(s, 3H), 1.45(s, 3H), 3.92(m, 1H, simplifies to d, J=8.9 Hz, with D2O), 4.98(m, 1H, simplifies to d, J=8.9 Hz, with D2O), 5.99(d, 1H, exchanges with D2O), 7.74(s, 1H), 7.92(d, J=8.5 Hz, 2H), 8.12(d, J=8.5 Hz, 2H) and 9.30 (d, 1H, exchanges with D2O).

Provenance & Evidence