Trifluoroacetic acid → 3-Formyl-2,4,6-trimethylbenzenesulfonyl fluoride

Participants

Reaction Steps

18.9 ml of 1,3,5-trimethylbenzene was reacted with 20 ml of fluorosulfonic acid and carbon monoxide in the presence of 10 ml of antimony pentafluoride and 10 ml of trifluoroacetic acid as a solvent at 20° C. for 48 hours in substantially the same manner as that of Example 1. The molar ratio of 1,3,5-trimethylbenzene : fluorosulfonic acid : antimony pentafluoride was 1 : 3.5 : 1.4, while the consumption of carbon monoxide was 2.24 λ. The same analyses as those of Example 1 were made to confirm the formation of 6.9 g of 3-formyl-2,4,6-trimethylbenzenesulfonyl fluoride (compound No. 7) in a yield of 30 % based on 1,3,5-trimethylbenzene. mass spectrum: M+ (m/e)=230.

Provenance & Evidence