Methyl chloroformate → Methyl 2-bromo-4-fluorobenzoate

HRID 1086667Notes

Reaction equation

HRID 1086667 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1O.[OH-].[Na+].Cl[C:13]([O:15][CH3:16])=[O:14]>O>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:13]([O:15][CH3:16])=[O:14]

Participants

5

Reactant 3

HCID 6586Methyl chloroformateHCID 14798Sodium HydroxideHCID 6054722-Bromo-4-fluorophenol

Product 1

HCID 7210837Methyl 2-bromo-4-fluorobenzoate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Bromo-4-fluorophenol (28 g) was added to a solution of sodium hydroxide (7 g) in water (100 ml), and methyl chloroformate was dropwise added thereto at a temperature of below 10° C. Precipitated crystals were collected by filtration and washed with water to give methyl (2-bromo-4-fluorophenyl)formate (41 g). M.P., 80.7° C.

Workup

  1. additionwas dropwise added
  2. customat a temperature of below 10° C
  3. customPrecipitated crystals
  4. filtrationwere collected by filtration
  5. washwashed with water

Sources & evidence

ORD record
ord-a00944830e0648a5a5aa4885822af9ab
Source dataset
uspto-grants-1991_07
Patent number
US05030760

Reaction notes

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