Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl 2-(chlorosulfonyl)-6-fluorobenzoate | HCID 14257491 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 4-Fluoro-2,3-dihydro-1lambda6,2-benzothiazole-1,1,3-trione | HCID 14257492 | — |
Reaction Steps
AT 20 to 28° C. and while stirring, 42.5 g of ammonia was gassed into mixture of 252.6 g (1 mol) of methyl 2-chlorosulfonyl-6-fluorobenzoate in 700 ml of anhydrous tetrahydrofuran. After the mixture had been stirred for an hour at 25° C., the precipitate was filtered off, dissolved in water, and extracted once with ethyl acetate. Acidification of the aqueous phase with concentrated hydrochloric acid gave 4% of theory of 4-fluoro-1,2-benzisothiazol-3-one-1,1-dioxide of m.p. 210 to 212° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05032167 |
|---|
| Source dataset | uspto-grants-1991_07 |
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| ORD ID | ord-b2cfde07ec824d8397ab2be02c3559aa |
|---|
| Source note | uspto-grants-1991_07 |
|---|
