Nitric Acid → HCID 15672162, compound

Participants

Reaction Steps

A mixture of conc. sulfuric acid (1.65 g) and conc. nitric acid (sp. gr. 1.38, 8.4 mmoles) was added dropwise to a solution of 4-chloro-3-(4-chloro-2-fluorophenyl)-1-methyl-5-methylthio-1H-pyrazole (0.98 g, 3.4 mmoles) in 2 ml conc. sulfuric acid under cooling with ice. After the addition was finished, the reaction mixture was further stirred for 2 hours at room temperature, and allowed to stand overnight. Then the resulting mixture was poured into ice-cold water, and the formed crystals were filtered off, washed successively with water and ether, and dried, crystals (1.04 g) of the title compound, m.p. 151.0° C., yield 87.5%.

Provenance & Evidence