HCID 15030572, compound → HCID 15671973, compound

HRID 1086751Notes

Reaction equation

HRID 1086751 reaction equation
[Cl:1][C:2]1[C:3]([C:10]2[CH:15]=[C:14]([S:16](Cl)(=O)=O)[C:13]([Cl:20])=[CH:12][C:11]=2[Cl:21])=[N:4][N:5]([CH3:9])[C:6]=1[S:7][CH3:8]>[Zn].C(O)(=O)C>[Cl:1][C:2]1[C:3]([C:10]2[CH:15]=[C:14]([SH:16])[C:13]([Cl:20])=[CH:12][C:11]=2[Cl:21])=[N:4][N:5]([CH3:9])[C:6]=1[S:7][CH3:8]

Participants

4

Reactant 1

HCID 15030572HCID 15030572, compound

Product 1

HCID 15671973HCID 15671973, compoundYield 89.1%

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 176Acetic AcidSolvent

Procedure

A mixture of 4-chloro-3-(5-chlorosulfonyl-2,4-dichlorophenyl)-1-methyl-5-methylthio-1H-pyrazole (7.71 g, 19 mmoles), 80 ml glacial acetic acid, and zinc dust (24.8 g, 380 mmoles) was subjected to reaction under reflux for 3.5 hours. The resulting solution was poured into ice-cold water, and the objective product was extracted with ethyl acetate. The extract solution was washed with water, dehydrated, and concentrated, giving the title compound (5.75 g) as oily matter, yield 89.1%.

Workup

  1. customwas subjected to reaction
  2. temperatureunder reflux for 3.5 hours
  3. additionThe resulting solution was poured into ice-cold water
  4. extractionthe objective product was extracted with ethyl acetate
  5. washThe extract solution was washed with water
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-a6e4a6a2d81a4e27a8c8bd40f6d77ef9
Source dataset
uspto-grants-1991_07
Patent number
US05032165

Reaction notes

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