1-Bromo-3,4,5-trifluorobenzene → HCID 178447975, compound

HRID 1086769Notes

Reaction equation

HRID 1086769 reaction equation
[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][CH2:11][C@H:12]2[CH2:17][CH2:16][C@H:15]([CH2:18][C:19](Cl)=O)[CH2:14][CH2:13]2)[CH2:6][CH2:5]1)[CH2:2][CH3:3].Br[C:23]1[CH:28]=[C:27]([F:29])[C:26]([F:30])=[C:25]([F:31])[CH:24]=1>>[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][CH2:11][C@H:12]2[CH2:17][CH2:16][C@H:15]([CH2:18][CH2:19][C:23]3[CH:28]=[C:27]([F:29])[C:26]([F:30])=[C:25]([F:31])[CH:24]=3)[CH2:14][CH2:13]2)[CH2:6][CH2:5]1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 6114091-Bromo-3,4,5-trifluorobenzeneHCID 178447977HCID 178447977, compound

Product 1

HCID 178447975HCID 178447975, compound

Procedure

Using trans-4-[2-(trans-4-propylcyclohexyl)ethyl]-cyclohexylacetyl chloride and a Grignard reagent prepared from 1-bromo-3,4,5-trifluorobenzene, as starting raw materials, 1-[trans-4-{2-(trans-4-propylcyclohexyl)ethyl}-cyclohexyl]-2-(3,4,5-trifluorophenyl)ethane was obtained in the same manner as in Example 2.

Sources & evidence

ORD record
ord-dcc3901f26194dcc98060054ab181aa0
Source dataset
uspto-grants-1991_07
Patent number
US05032313

Reaction notes

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