Acetyl chloride → HCID 18783754、化合物

関与物質

反応手順

3,4,5-Trifluorophenol (5.0 g, 0.034 mol), which was obtained by reacting a Grignard reagent of 1-bromo-3,4,5-trifluorobenzene with acetyl chloride, oxidizing the resulting 1-acetyl-3,4,5-trifluorobenzene with a peracid to obtain 3,4,5-trifluorophenyl acetate and subjecting this acetate to hydrolysis reaction, was dissolved in dry pyridine (10 ml), followed by gradually adding trans-4-propyl-cyclohexylcarbonyl chloride (6.4 g), allowing the resulting reaction solution to stand at 50° C. for 3 hours, adding water (100 ml) to the reaction solution, extracting the resulting deposited oily substance with n-heptane (30 ml), washing the n-heptane solution with a dilute hydrochloric acid aqueous solution and then with a dilute alkali aqueous solution, further washing with water till the washing water became neutral, drying the n-heptane solution over anhydrous sodium sulfate, distilling off n-heptane and recrystallizing the resulting oily substance from ethyl alcohol to obtain 3,4,5-trifluorophenyltrans-4-propylcyclohexyl carboxylate (6.5 g).C-I: 4.5° C.

情報源と証拠