HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1086771Generated: October 31, 2026
Tris(hydroxymethyl)aminomethane → HCID 131716326, compound
https://huagongshe.com/reaction/1086771
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tris(hydroxymethyl)aminomethane | HCID 6503 | — |
| Reactant | epsilon-CAPROLACTONE | HCID 10401 | — |
| Reactant | 2-Oxazolidinone | HCID 73949 | — |
| Product | HCID 131716326 | HCID 131716326 | — |
Reaction Steps
About 121.0 g (1.0 mole) of 2-amino-2-(hydroxymethyl)-1,3-propanediol (THAM) was combined with 114.0 g (1.0 mole) of E-Caprolactone and 0.1 g stannous octanoate Sn(OCT)2. As the reaction mixture was slowly heated to 150° C., a clear solution was obtained. Infrared analysis of the reaction product showed no unreacted caprolactone. Upon heating the product cyclized to a hydroxy-oxazoline, and a strong absorption band at 6.0 microns in the infrared spectrum was observed. The product analyzed for 50.94% C, 9.29% H and 5.79% N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05032320 |
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| Source dataset | uspto-grants-1991_07 |
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| ORD ID | ord-4847f29437da4823879813957812e954 |
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| Source note | uspto-grants-1991_07 |
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