化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 2,4-dibromobutanoate → 3-hydroxy-1-methylpyrrolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 2,4-dibromobutanoate | HCID 296716 | — |
| 反応物 | 3-hydroxy-1-methylpyrrolidin-2-one | HCID 10313118 | — |
| 反応物 | 2,4-Dibromo-N-methylbutanamide | HCID 15067983 | — |
| 生成物 | 3-hydroxy-1-methylpyrrolidin-2-one | HCID 10313118 | — |
| 生成物 | 3-Bromo-1-methylpyrrolidin-2-one | HCID 11182954 | — |
反応手順
There is also provided by this invention a method for preparation of 3-hydroxy-N-methylpyrrolidone which comprises conversion of delta-butyrolactone to methyl-2,4-dibromobutyrate, conversion of the methyl-2,4-dibromobutyrate to N-methyl-2,4-dibromobutyramide, ring closure of the N-methyl-2,4-dibromobutyramide to form 3-bromo-N-methyl-2-pyrrolidone, and conversion of the 3-bromo-N-methyl-2-pyrrolidone to 3-hydroxy-N-methyl-2-pyrrolidone by reaction with alkali metal carbonate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05032402 |
| 出典データセット | uspto-grants-1991_07 |
| ORD ID | ord-c84d61d8a20e4afe9083ce44fa6606f8 |
| 出典メモ | uspto-grants-1991_07 |