Boc-Gly-Gly-Val-Pro-OBzl → Boc-Gly-Gly-Val-Pro-OH

HRID 1086787Notes

Reaction equation

HRID 1086787 reaction equation
[NH:1]([C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])[CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][C@H:10]([C:14]([N:16]1[CH2:30][CH2:29][CH2:28][C@H:17]1[C:18]([O:20]CC1C=CC=CC=1)=[O:19])=[O:15])[CH:11]([CH3:13])[CH3:12])=[O:8])=[O:4]>C(O)(=O)C>[NH:1]([C:31]([O:33][C:34]([CH3:36])([CH3:35])[CH3:37])=[O:32])[CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][C@H:10]([C:14]([N:16]1[CH2:30][CH2:29][CH2:28][C@H:17]1[C:18]([OH:20])=[O:19])=[O:15])[CH:11]([CH3:13])[CH3:12])=[O:8])=[O:4]

Participants

3

Reactant 1

HCID 14306249Boc-Gly-Gly-Val-Pro-OBzl

Product 1

HCID 14306251Boc-Gly-Gly-Val-Pro-OH

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

IV (6.2 g, 0.012 mole) in acetic acid was hydrogenated and worked up as for IIto obtain V quantitatively, no sharp m.p. 74°-83° C. Rf3, 0.25; Rf4, 0.15. Anal. Calcd. for C19H32N4O7 : C, 51.10: H, 7.67; N, 12.54%. Found: C, 51.28: H, 7.50 N, 12.38%.

Workup

  1. customobtain V quantitatively

Sources & evidence

ORD record
ord-b0ea5b24149e4cb4a5bf46b6d3646aca
Source dataset
uspto-grants-1991_07
Patent number
US05032271

Reaction notes

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