Fumaric Acid → HCID 131716951, compound

Participants

Reaction Steps

Fumaric acid (1.2 g) was added to a refluxing solution of N-[(1S,trans)-2-hydroxycyclopentyl]adenosine (7.03 g) in isopropanol (105 ml). The resulting hot solution was filtered, and the filtrate was cooled and allowed to crystallise. After 2 h at 20° the crystalline product was isolated by filtration, washed with isopropanol (10 ml) and dried in vacuo at 50° for 20 h to give the title compound (6.5 g), m.p. 179°-180°. The chromatographic behaviour of this salt resembled that of an authentic sample of the free base.

Provenance & Evidence